Evolutionary couplings and predicted 3D folds for transmembrane proteins compared to known 3D structures.
The fold accuracy is measured by TM score - Template modeling scores (range 0.0 - 1.0). TM score is consided reasonable when > 0.5.
Cα-RMSD - root-mean-square deviation in Å (number of residues).
Meff is the effective number of sequences in the alignment after weighting by the number of sequences with sequence identity above a similarity threshold.
| Uniprot ID | PFAM | TM Helices | Length | E-Val | Meff | Seq/len | TM Score | Cα-RMSD | PDB | Download link |
|---|---|---|---|---|---|---|---|---|---|---|
| ADIC_SALTY | PF00324 | 12 | 444 | 5 | 40524 | 91.27 | 0.79 | 3.3 (365) | 3ncyA | download_results |
| ADRB2_HUMAN | PF00001 | 7 | 341 | 40 | 14684 | 43.06 | 0.72 | 3.0 (224) | 2rh1A | download_results |
| ADT1_BOVIN | PF00153 | 6 | 297 | 35 | 10474 | 35.27 | 0.62 | 3.8 (199) | 1okcA | download_results |
| AMTB_ECOLI | PF00909 | 10 | 409 | 30 | 4644 | 11.35 | 0.68 | 3.7 (275) | 1xqfA | download_results |
| AQP4_HUMAN | PF00230 | 6 | 241 | 5 | 5636 | 23.39 | 0.52 | 3.2 (117) | 3gd8A | download_results |
| BTUC_ECOLI | PF01032 | 10 | 324 | 15 | 10708 | 33.05 | 0.77 | 3.0 (260) | 1l7vA | download_results |
| C3NQD8_VIBC | PF01554 | 12 | 459 | 40 | 14714 | 32.06 | 0.74 | 4.1 (381) | 3mktA | download_results |
| C6E9S6_ECOBD | PF00361 | 14 | 479 | 70 | 10665 | 22.27 | 0.82 | 3.5 (423) | 3rkoN | download_results |
| COX1_BOVIN | PF00115 | 12 | 513 | 120 | 4079 | 7.95 | 0.78 | 3.7 (421) | 1occA | download_results |
| COX3_BOVIN | PF00510 | 7 | 259 | 20 | 4511 | 17.42 | 0.69 | 2.9 (191) | 1occC | download_results |
| CYB_BOVIN | PF00032/33 | 8 | 378 | 100 | 3727 | 9.86 | 0.66 | 3.9 (268) | 1pp9C | download_results |
| FIEF_ECOLI | PF01545 | 6 | 299 | 10 | 9802 | 32.78 | 0.63 | 2.6 (131) | 3h90A | download_results |
| GLPG_ECOLI | PF01694 | 6 | 192 | 15 | 6778 | 35.30 | 0.68 | 2.6 (132) | 3b45A | download_results |
| GLPT_ECOLI | PF07690 | 12 | 449 | 40 | 45965 | 102.37 | 0.80 | 3.4 (363) | 1pw4A | download_results |
| METI_ECOLI | PF00528 | 6 | 216 | 20 | 22524 | 104.28 | 0.50 | 3.2 (108) | 3dhwA | download_results |
| MIP_BOVIN | PF00230 | 6 | 229 | 20 | 5173 | 22.59 | 0.63 | 3.1 (150) | 1ymgA | download_results |
| MSBA_SALTY | PF00664 | 6 | 323 | 60 | 12030 | 37.24 | 0.64 | 3.4 (215) | 3b60A | download_results |
| O67854_AQUAE | PF00209 | 12 | 512 | 20 | 4544 | 8.88 | 0.70 | 4.0 (377) | 2a65A | download_results |
| OPSD_BOVIN | PF00001 | 7 | 347 | 40 | 16007 | 46.13 | 0.73 | 2.9 (240) | 1hzxA | download_results |
| TRKH_VIBPA (Q87TN7_VIBPA) | PF02386 | 8 | 441 | 10 | 4462 | 10.11 | 0.64 | 4.0 (286) | 3pjzA | download_results |
| Q8EKT7_SHEON | PF00854 | 12 | 515 | 40 | 4490 | 8.72 | 0.65 | 3.9 (332) | 2xutA | download_results |
| Q9K0A9_NEIMB | PF01758 | 10 | 314 | 10 | 6315 | 20.11 | 0.60 | 4.4 (295) | 3zuxA | download_results |
| SGLT_VIBPH (SGLT_VIBPA) | PF00474 | 14 | 519 | 20 | 9949 | 19.17 | 0.65 | 4.4 (349) | 2xq2A | download_results |
| TEHA_HAEIN | PF03595 | 10 | 327 | 5 | 1940 | 5.93 | 0.67 | 3.6 (229) | 3m71A | download_results |
| URAA_ECOLI | PF00860 | 14 | 419 | 5 | 14753 | 35.21 | 0.53 | 4.5 (220) | 3qe7A | download_results |
| NQO8_THET8* | PF00146 | 9 | 365 | 20 | 5060 | 15.34 | 0.73 | 2.9 (220) | 4he8C | download_results |
| GTR1_HUMAN* | PF00083 | 12 | 492 | 30 | 21405 | 43.59 | 0.80 | 3.6 (405) | 4pypA | download_results |
| TSPO_MOUSE* | PF03073 | 5 | 169 | 3 | 2347 | 13.97 | 0.61 | 3.0 (106) | 2mgyA | download_results |
| Y091_METJA* | PF01699 | 10 | 302 | 15 | 5361 | 17.81 | 0.65 | 3.9 (218) | 3v5uA | download_results |
Four of the predictions from 2012 paper have now been solved experimentally.