Transmembrane Protein 3D Structures - Predicted by Evolutionary Couplings

2012 Prediction results of individual protein domains that have UNKNOWN structures

Evolutionary couplings and 3D folds for membrane proteins that have unknown 3D structures.

Top # is the number of evolutionary constrains used and model number of blind top-ranked and best-generated model, respectively.

Meff is the effective number of sequences in the alignment after weighting by the number of sequences with sequence identity above a similarity threshold.

Uniprot ID PFAM TM Helices Modeled Length E-Value Meff Seq/Len Top Randked Model Download link
ADR1_HUMAN PF03006 7 223 5 827 3.71 150-14 download_results
NU1M_HUMAN* PF00146 8 282 10 774 3.4 210-18 download_results
S22A4_HUMAN* PF00083 12 373 30 4817 12.9 220-11 download_results
ABCG2_HUMAN PF01061 7 274 10 1553 5.7 210-3 download_results
ELOV4_HUMAN PF01151 7 233 3 491 2.1 190-6 download_results
SL9A1_HUMAN PF00999 13 367 10 1402 3.8 210-17 download_results
MSMO1_HUMAN PF04116 5 220 20 229 1.01 70-13 download_results
S13A1_HUMAN PF00939 15 543 20 443 0.82 140-7 download_results
EAMA_ECOLI PF00892 10 276 5 8278 30 250-10 download_results
LIVH_ECOLI PF02653 8 282 3 5385 19.1 230-16 download_results
GABR1_HUMAN PF00003 7 298 5 431 1.4 190-19 download_results
B1B3L4_STAAU PF05569 6 585 10     130-5 download_results
CCG1_HUMAN PF04193 4 222 3     60-4 download_results
CTNS_HUMAN PF05569 7 367 3     160-6 download_results
NAC1_HUMAN PF03160 5 493 15     150-16 download_results
S5A1_HUMAN PF02544 7 259 5     170-16 download_results
TSPOA_HUMAN* PF03073 5 169 5     60-9 download_results
VIAAT_HUMAN PF01490 11 525 5     320-4 download_results

* How did we do?

Three of the predictions from 2012 paper have now been solved experimentally.

Click here for the predictions and the comparisons with the experimental structures.

Click here to the current prediction results table.